Sailgene Technology
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Sailgene Technology
Introduction
Meta Hi-C sequencing is defined as a technology that integrates Hi-C technology with metagenomic sequencing. Based on the technical principles of Hi-C, all microorganisms in the sample are subjected to fixation and cross-linking, restriction enzyme digestion, proximal DNA ligation, and capture processes to obtain spatially proximal DNA fragments, followed by metagenomic library construction and sequencing.
Applications
Detection of the relationship between antibiotic resistance genes and hosts, research on the transfer and spread of antibiotic resistance genes
Detection of the relationship between plasmids and hosts
Detection of the relationship between mobile genetic elements and hosts
Detection of the relationship between bacteriophages and hosts
Product Advantages
Decipher microbial spatial interaction networks
Enhance microbial genome assembly quality
Precisely link functional genes to host microbes
Unveil spatial organization patterns of microbial communities
Integrate three-dimensional information
Workflow
Sequencing
Platform：illumina
Technical Principle
Data Delivery Format
FASTQ
Comparison with Other Technologies
|
Dimension |
Hi-C Technology |
Meta Hi-C Technology |
|
Technical Position |
Analysis of 3D chromatin structure in a single species |
Interaction analysis among complex microbial communities |
|
Research Object |
Single species |
Complex microbial mixed samples |
|
Application Scenario |
Research on 3D genome structure and gene regulation mechanism of a single species |
Analysis of host-plasmid/ARGs associations and species interactions in complex microbial communities |
|
ore Purpose |
Construct chromosome-level genome of a single species and analyze chromatin interactions |
Analyze horizontal gene transfer and host-mobile element associations in microbial communities |
Article Case
|
Data |
Journal |
Impact Factor |
Title |
|
2025.9 |
Nature Microbiology |
19.4 |
Phages with a broad host range are common across ecosystems |
|
2024.3 |
Nature Communications |
16.6 |
Host- plasmid network structure in wastewater is linked to antimicrobial resistance genes |
|
2023.11 |
Nature Communications |
16.6 |
Hi-C metagenome sequencing reveals soil phage–host interactions |
|
2022.1 |
Nature Biotechnology |
54.9 |
Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities |
|
2021.2 |
Elife |
10.8 |
MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut |
Sample Submission Requirements
Meta HiC Sequencing pecifications:
|
Sample Type |
Weight |
Precautions |
|
Feces |
2~5 g |
Store at -80℃ and transport on dry ice |
|
Soil |
5~8 g |
Other types of samples can be consulted with the application scientist
Keyword:
Meta HiC Sequencing
Contact Us
If you are interested in our long-read sequencing services or potential collaboration, please contact us. Our team is ready to support your research with tailored solutions. We also welcome feedback from users to help us improve our services.
Contact Us
Add: 82 Wendell Avenue, Pittsfield, Massachusetts, USA
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