Sailgene Technology
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Sailgene Technology
Introduction
Conformation capture (3C) with Nanopore long-read sequencing, enabling the detection of multi-locus interactions andassociated DNA methylation pattems within genomes. Its streamlined workflow eliminates theneed for biotin labeling or PCR amplification, while effectively capturing complex GC-rich andrepetitive regions-all while preserving epigenetic information.Pore-C offers deeper insights into chromatin interactions, facilitates the distinction of allelicgenes, and significantly enhances the quality of genome assemblies in both animals and plants.It also helps correct misassemblies and supports advanced research into the three-dimensionalspatial organization of the genome and multiplex chromatin interactions.
Applications
3D genome research
Improving assembly contiguity
Efficient Haplotype-resolved Assembly
DNA methylation modification and chromosome structure relationship research
Highlights
Capable of detecting a greater number ofhigher-order interactions
The absence of an amplification step that isrequired in other chromatin conformationcapture methods
Bisulfite conversion (as is required in Methyl-HiC) is not required when detecting DNAmethylation.
Upgraded flow cells and basecalling modelsachieve Super Accuracy Reads with amedian Q score of up to Q28.
Pore-C improves interaction data in complex regions,helping to locate complex contigs on chromosomes
Publications
|
Year |
Journal |
Impact Factor |
Title |
| 2024 | Horticulture Research | 8.5 | A telomere-to-telomere gap-free reference genome assembly of avocado provides useful resources for |
| 2022 | Plant Biotechnology Journa | 6.3 | Multi-omics mapping of chromatin interaction resolves the fine hierarchy of 3D genome in allotetraploid cotton |
Contact Us
If you are interested in our long-read sequencing services or potential collaboration, please contact us. Our team is ready to support your research with tailored solutions. We also welcome feedback from users to help us improve our services.
Contact Us
Add: 82 Wendell Avenue, Pittsfield, Massachusetts, USA
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